Comments on: A cure for type 1 diabetes

By: lorna

lorna — Wed, 08 May 2013 04:50:35 +0000

I have type 1 and they never know why but do come up with all different ideas. i have never heard of it from trauma? What type of trauma? Wonder if I am ibn that group? Thank you

By: Concerned Citizen

Concerned Citizen — Mon, 06 May 2013 21:09:16 +0000

Lots of red tape when animal trials move to humans, as the governement does not want to be responsible for the death of 1 human in a clinical trial (though they gladly kill people in war all the time), even though many humans would volunteer to take on the risk. It is said that insulin would not make it to human trials if it was discovered today.

By: Concerned Citizen

Concerned Citizen — Mon, 06 May 2013 21:05:29 +0000

What about those who have T1D, but as a result of a trauma instead of an autoimmune response? This may provide a cure for that group of people.

By: Concerned Citizen

Concerned Citizen — Mon, 06 May 2013 21:03:49 +0000

This is the key. If they can cure a dog which has T1D naturally (as opposed to induced), then there may be hope for the millions alive today, and the billions who will follow in the future.

That should be the next test.

By: milkseed3@verizon.net

milkseed3@verizon.net — Sun, 14 Apr 2013 11:42:51 +0000

I was 9 when my family received a complementary newspaper. The cure for diabetes was the big story. My Mom and I cried as she read the story.. That was 1955. I can’t remember how many times since I have read about ‘the cure’.

By: Angel

Angel — Thu, 04 Apr 2013 08:03:00 +0000

I hope ,God may bless you for your dream will come true in one day .
I will really pray for that.

By: victor

victor — Thu, 28 Feb 2013 23:06:13 +0000

… and your message brought tears to my eyes…

By: victor

victor — Thu, 28 Feb 2013 23:05:21 +0000

Try to reach the original authors of the paper, by email or phone, whatever!

By: victor

victor — Thu, 28 Feb 2013 23:03:27 +0000

Hi Teresa. My father died of type 1 diabetes 15 years ago, when he was only 45 (yes, at the end he had the whole bunch of troubles, including blindness and kidney failure).
I sympathize with you and I wish you all the best luck at the trials, for this one, or maybe with those with artificial pancreas. (You have probably read about that one too, on this website).

By: Luke

Luke — Thu, 28 Feb 2013 14:32:38 +0000

Side effects of drugs to make a pancreas transplant work lead to cancer and other concequences. It’s detailed on the mayo clinics website. It’s not a viable option for diabetics.

By: Teresa

Teresa — Thu, 28 Feb 2013 05:43:44 +0000

I have had type 1 almost all my life and suffer almost all the complications including amputation, kidney disease, digestive issues, and eye and heart problems how would I sign up if they decided to try it on humans they can experament on me anytime, I am only 50 yrs old and things arent looking to good about making it to 60

By: Tina

Tina — Sat, 23 Feb 2013 16:51:52 +0000

WOW! This news actually brought tears to my eyes…a cure for Type 1 diabetes! I have had Type 1 diabetes for 59 years, since I was 2 yrs. old…I am now 61 and my dream was to see a cure before I die! Who knows…my dream may come true yet!!!

By: Carley Moore

Carley Moore — Tue, 19 Feb 2013 07:59:59 +0000

Actually they have found that a Pancreas transplant surgery has cured

By: Jeff

Jeff — Mon, 18 Feb 2013 19:30:32 +0000

The damn Government dont want the cure for Cancer, HIV, Type 1 and 2 diabetes. The Pharmacy companies and Doctors and hospitols and insurance companies then wont be able to line there pockets

By: Editor

Editor — Sun, 17 Feb 2013 04:30:31 +0000

The researchers do not mention studies in the U.S., but they do thank M. Watford (Rutgers University, NJ) for technical assistance. The corresponding author for the paper is Fatima Bosch, fatima.bosch@uab.es. She may have some suggestions.

By: Wes Bertrand

Wes Bertrand — Sun, 17 Feb 2013 00:22:40 +0000

Unfortunately, this is no cure for type 1 diabetic humans, not by a long shot. In order for a cure to happen, the autoimmune attack on beta cells by T-cells needs to be addressed, which this study did not do. The reason why these researchers achieved success in these canines with this treatment is because their type 1 was induced deliberately (chemically) by the researchers; the dogs had normal functioning immune systems, so the newly viable insulin-producing cells in their muscle tissue were not attacked. This article is informative about this:
http://www.medicinenet.com/script/main/art.asp?articlekey=167821

My bet at this point is on the “re-education” of my T-cells via cord blood stem cells (I’ve been TD1 since ’95), as done in the following Chinese study. (Whether the people calling themselves the “FDA” will oppose or impede it is the coercive factor to consider.)
Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
http://www.biomedcentral.com/1741-7015/10/3/abstract

By: Chris

Chris — Sat, 16 Feb 2013 21:17:34 +0000

I have a rat terrier who has canine diabetes mellitus and would love him to have the same treatment. Where in the USA are they having these studies and these experimental treatments done. I am there! So tired of having to give him 2 insulin injections a day and I think he is also. He is a young dog and still has a very long life ahead of him, hopefully, with this treatment they are talking about.

By: Joshua Cintron

Joshua Cintron — Sat, 16 Feb 2013 19:35:06 +0000

I am elated, just as you are a cure for humans is right around the corner. My dad has type II diabetes, so I wonder how or if that may be curable as well.

By: jp

jp — Sat, 16 Feb 2013 16:59:33 +0000

Just because tech is moving very fast does not mean it will be a nice place to live.

By: Daphne

Daphne — Sat, 16 Feb 2013 03:14:16 +0000

My God! I’m so tired of living with Type 1 Diabetes, and all the misery, and effects of long term survival with this disease. For 37 years it’s been a rock in my shoe, to understate it. I hope, and pray that my mother’s prayers are FINALLY coming true, that she will live to see the day I, and others like me, am set free from this condition.

By: V.

V. — Fri, 15 Feb 2013 21:09:48 +0000

It always says “This works on animals, dogs”

But when are the medicine coming to humans?

By: Bri

Bri — Fri, 15 Feb 2013 03:28:58 +0000

I was thinking similar thoughts. It looks like we are coming into the era of human gene therapy that’s been promised for so long.

By: Irena

Irena — Fri, 15 Feb 2013 00:56:09 +0000

Please understand that there are lean type 2′s-not everyone with type 2 diabetes is overweight. There has been a lot in the literature about lean type 2 diabetics-very important to know this information and to refrain from making generalizations. Overweight/obesity is very complex and much more than not pushing away from the table soon enough.

By: Gabriel

Gabriel — Thu, 14 Feb 2013 23:23:57 +0000

Fantastic news! This should be headline news everywhere I go….that they were successful in treating this disease means that, what comes next, will be translation of the results into human therapies.

By: Ian Clarke

Ian Clarke — Thu, 14 Feb 2013 21:33:19 +0000

Likewise, Gorden.

I think it wise for us all to stay as healthy as we can, both physically and mentally. I hope I’m here for the Singularity, but I think that the path to it will be amazing and I just want to see as much of it as I possibly can.

By: Vin

Vin — Thu, 14 Feb 2013 20:57:27 +0000

So exciting. So muscle becomes a surrogate pancreas after just one treatment? Amazing. These AAV’s and that recent nanoshell protien complex delivery seem like 2 quite recent advances for gene therapy and who knows what else. Guess it’ll soon be 4.

By: Gorden Russell

Gorden Russell — Thu, 14 Feb 2013 20:31:40 +0000

Always glad to hear from you, Ian.

By: Erik

Erik — Thu, 14 Feb 2013 19:37:38 +0000

I thought the problem with gene therapy was that it needs to be administered repeatadly and there is an increased risk of cancer.

The article implies thas is not true anymore, at least not for dogs. Does it mean we may be able to cure other genetic diseases using the same method?

That would be awesome.

By: gaoptimize

gaoptimize — Thu, 14 Feb 2013 18:42:14 +0000

Potentially the biggest billion dollar implication story of the year. Oh, and I’m happy for the little dog in the picture.

By: infinitos

infinitos — Thu, 14 Feb 2013 17:30:41 +0000

so will this also cure type 2 also ??

By: Ian Clarke

Ian Clarke — Thu, 14 Feb 2013 17:02:51 +0000

Gorden, I keep visiting this site to maintain my optimism about the future. If I only watched the ordinary news, it would be easy to assume that technology & innovation were pretty much stagnant (or at least moving slowly). Not all the stories published here have the ‘wow factor’ but they’re enough to assure me that very clever folk are working hard to move us into a brighter future. It’s only in the last few years that I’ve started to believe I’m living in the future I dreamed of as a kid. Unfortunately, after reading Ray’s ‘The Singularity Is Near’, my expectations have risen considerably. :-)

By: craig

craig — Thu, 14 Feb 2013 16:59:03 +0000

This is for type 1

Type II can often be managed by not eating so darned much carbohydrates and calories in total. They often have high insulin but their body is stocked full of as much sugar and fat as the cells want so they won’t accenpt anymore

By: Rob

Rob — Thu, 14 Feb 2013 16:52:43 +0000

I wonder if they will study Glucokinase in the treatment of Tye II diabetes. It may help with the insulin resistance that is the hallmark of the disease. It’s a simpler solution than waiting around for personalized organs like eyes and kidneys. Plus no surgery.

By: Gorden Russell

Gorden Russell — Thu, 14 Feb 2013 15:04:40 +0000

Even if it is the least common of the two types of diabetes, there are still a lot of sufferers who will be helped if this cure works. This also means that there will be more people who will live to see the Singularity. That’s why we all keep visiting this site, isn’t it? Don’t you want to make it to the time when exponential progress will be so great that the exponent has an exponent? That’s the time that Ray Kurzweil projects that the lines on the graphs all go off-chart up and to the right. Just check out his book again and look at all his graphs. His projections have been coming true since the ’90s.

By: Richard

Richard — Thu, 14 Feb 2013 14:59:02 +0000

American Diabetes Association
Innovative Immune Cell Re-education Technique Holds Promise for Type 1 Diabetes
http://www.diabetes.org/news-research/research/research-discoveries/recent-advances/innovative-immune-cell.html

By: Joe

Joe — Thu, 14 Feb 2013 14:39:10 +0000

This study involves Type I diabetes. Type II is far more common. Type I involves loss of insulin-producing cells in the pancreas. Type II diabetics can make insulin but they have insulin resistance, i.e., the insulin receptor in the cells doesn’t accept the insulin. Thus curing Type II requires a different mechanism.

By: TomInWales

TomInWales — Thu, 14 Feb 2013 14:19:00 +0000

Err, and human trials begin when?

By: dan

dan — Thu, 14 Feb 2013 14:06:33 +0000

Type 1 diabetics produce little to no insulin due to autoimmune destruction of the beta cells in the pancreas.

Type 2 diabetics also inject insulin sometimes.

Is this a cure for type 2 or type 1?

By: Luc Dufrane

Luc Dufrane — Thu, 14 Feb 2013 13:27:26 +0000

buh-bye diabetes – rest in peace, we won’t regret you :-)