A Laser Gets at the Layers

August 18, 2004 | Source: New York Times

A new “selective plane illumination microscope” uses a slice of laser light to illuminate an intact specimen one thin layer at a time, building a high-resolution picture of the entire specimen without cutting it.

Samples can be kept alive and studied for hours or days while tissues develop and differentiate. The scientists say the microscope has better resolution than other living-sample imaging techniques, like multiphoton microscopy.