Computer modeling: brain in a box
February 23, 2012
Henry Markram’s controversial proposal for the Human Brain Project (HBP) — an effort to build a supercomputer simulation that integrates everything known about the human brain, from the structures of ion channels in neural cell membranes up to mechanisms behind conscious decision-making — may soon fulfill his ambition.
The project is one of six finalists vying to win €1 billion (US$1.3 billion) as one of the European Union’s two new decade-long Flagship initiatives.
The HBP would integrate these discoveries, he said, and create models to explore how neural circuits are organized, and how they give rise to behavior and cognition. Ultimately, said Markram, the HBP would even help researchers to grapple with disorders such as Alzheimer’s disease.
He proposed to model everything, “from the genetic level, the molecular level, the neurons and synapses, how microcircuits are formed, macrocircuits, mesocircuits, brain areas — until we get to understand how to link these levels, all the way up to behavior and cognition.”
The computer power required to run such a grand unified theory of the brain: roughly an exaflop, or 1018 operations per second, to be available in exascale computers by the 2020s.
So far, his team at he Swiss Federal Institute of Technology in Lausanne (EPFL) has simulated 100 interconnected columns.
Henry Markram speaking at the 2011 International Supercomputing Conference
[ Nature News ]

Comments (17)
by libra9
I think the big challenge will be to simulate the multi levels of neurons such that the sum of the parts acts like the whole. Remember the principle of irreducibility.
by andmar74
I don’t understand the sceptics in the article. Even if Markram et al doesn’t succeed in building a whole model for the brain, all the data that goes into the project, and the software that manages it, should be almost priceless for the neuroscientists.
by Ralph Dratman
@Micheal Karg
What I am worrying about in my message is not going to happen tomorrow or next year. It is probably decades away. But the pilotless drones are very disturbing right now,.Recently I read about an experimental deployment of drones that actually fly themselves for most of the journey, without even requiring a human operator. The military might go far in that direction before we collectively have any clue about how to regulate such frightening devices.
by tim the realist
So you don’t mind the humans participating in war – it’s just the idea of a human brain in a synthetic medium conducting war that bugs you?
by melajara
I’ve the strong “feeling” that true feelings are qualia experienced/mediated through a large set of chemical processes not addressed by this simulation however ambitious it might be.
Besides, without true proprioceptive abilities, this “brain” will be totally alien to what is human condition (in its onto-genetic development).
Most probably, the end product of this simulation will be a brain suffering from a severe form of autism .
Ironically, Markram and his wife are utmost interested by autism as they have a child suffering from this condition, so, in a way Markram is ready.
by Petri J
After reading your comment, I have a strong “feeling” that you didn’t even see the youtube video and yet you are ready to post such criticism.
by melajara
@Petri J
Actually I saw that video months ago and I was very enthusiastic about the whole project. Btw I’m following Markram’s work for several years and that’s emphasized by the fact that I’m living just 25km from his current lab. It is yet the most consistent and biologically faithful large scale brain reconstruction attempted so far I know about.
Now that the project could receive a huge funding I would like, as in a somewhat prophylactic way, to recuse the damaging hype and hypocritical coverage coming with big bucks and the associated fame of such a large scientific project in the medias.
Even the label “team Frankenstein” – maybe a good joke in a small and relatively unnoticed scientific team – could become a terrible blunder in the face of huge fund raising depending from inescapable political involvement. And so about an hypothetical artificial consciousness emerging at the end of the quest and the associated possible ethical concerns about the potential abuse performed against a new “sophont”.
My rambling was just a sort of “caveat emptor” to debunk irrelevant claims about the possible achievements of such a project, even after 10 years of dedicated work and $1.3 billion spending, no more no less.
by Ralph Dratman
Such a project might do some good by enhancing our understanding of various forms of mental illness and other disease patterns, of the type that might plausibly be investigated as functional brain disorders. I would not personally fear or oppose this, as long as the brain is not given a body or any other human- or animal-like interaction capabilities. But of course that will be done too. The appeal of the golem, the android or Frankenstein’s constructed man will be too strong for us. Collectively, we weak, easily temptable humans can and will resist nothing, despite concerns that the brain simulation would develop autonomy, acquire money, and eventually control weapons.
This also raises the fear of cruelty to, for or by the brain machine. Can a human be cruel to a machine? Can a brain simulation feel some sort of urge to be cruel to humans or other living things?
My other worry — again almost a certainty — is that the world’s military powers will find reasons and methods aimed at somehow using such a simulation as part of a weapon of war. Every new technology is so employed. That inevitable course leads right back to providing the brain with some kind of body, weapons and even control of money (as, say, a secret agent).
Of course it does not matter whether I or anyone else fears such an undertaking. Our present life-and-death connection with technological objects means that this, or a similar project, will eventually succeed in building some kind of brain, which will then be employed in some good ways as well as in many harmful harmful ways. If things continue as they are — in terms of our rate of energy-using growth — such developments become inevitable.
by Micheal Karg
@Ralph Dratman
As i understand it(and please correct me if i’m wrong), this project doesn’t try to reproduce a living brain for direct simulation, but instead offer a open knowledge center(or knot) for studying how the brain functions.
this means that scientists will be able to test thesis and drugs on a functioning brain model instead of doing animal testing and trials.
Of course eventually this project will be used as a resource for the AI people to understand how real intelligence is done in nature, which will enable us to build truly intelligent machines that work on those principles.
We are just at the very beginning of this journey and we’ll just have to wait and see what’s
going to come from all this.
But nevertheless i’m very excited and wish Henry Markram and his team all the best and most importantly all the brainpower they need!
Greetings
Michael
by gaoptimize
@Ralf Dratman
“My other worry — again almost a certainty — is that the world’s military powers will find reasons and methods aimed at somehow using such a simulation as part of a weapon of war. Every new technology is so employed.”
Not to worry, the porn industry always beats the military in implementing any new technology. So, regulators at the SEC and bureaucrats everywhere will be too occupied with brain stimulation for some brain simulation to get money and weapons. Besides, we already have a practical map of the brain: http://www.myspacegraphicsandanimations.com/images/MaleBrain_6-22-06.gif
and if anything, you should worry about a run up in the prices of hookers and blow.
by tim the realist
@Ralph
Ralph – the military already has hundred of thousands of 100% accurate brain simulations at their disposal – they are called war fighters.
by mental
@gaoptimize
The Swiss Blue Brain project is actually the Human Brain Project. They just changed the name for this funding occasion. “Blue Brain” was sort of a “internal name”.
Hope to see news from this, given the effort of EPFL in the last 20 years I hope they get the funds.
by YoungCaesar
I love this. With 1.3 billion dollars I think it could go far.
by Dizzle
I hope they don’t try to duplicate the brain. It’s good but so inefficient and oh so riddled with blood lust, justice, religion, etc.. You know the story.
Read my .99cent ebook. It’s 2048 and It Happened at Nextfest.
http://www.amazon.com/dp/B004RD9EEY/
by Tom
By reverse engineering and modeling the brain we will have a far better understanding of learning and intelligence (not to mention brain diseases). This knowledge will help us do it right in our AI algorithms. The point isn’t to duplicate lots of artificial human brains with all of their imperfections.
by gaoptimize
And what of the Swiss Blue Brain project? bluebrain.epfl.ch. Again?
by Micheal Karg
now that’s what i’m talking about