Fluorescent puppy is world’s first transgenic dog

April 24, 2009 | Source: NewScientist Life

A cloned beagle named Ruppy (Ruby Puppy) is the world’s first transgenic dog. She and four other beagles all produce a fluorescent protein that glows red under ultraviolet light.

(Byeong Chun Lee)

(Byeong Chun Lee)

A Seoul National University team created the dogs by cloning fibroblast cells that express a red fluorescent gene produced by sea anemones.

This new proof-of-principle experiment is intended to open the door for transgenic dog models of human disease.