Gene switch rejuvenates failing mouse brains

May 7, 2010 | Source: New Scientist Life

An acetyl “cap” genetic switch that causes memory impairment in aging mice when it goes into “off” mode has been flicked on by European Neuroscience Institute scientists.

The result was increased activity of a cluster of more than 1500 genes that make proteins needed for the creation of new neurons, thus restoring failing brains to a more youthful state.

Drugs to treat cancer in people also promote acetyl cap binding, and with some modifications, they could be exploited to improve brain function in people with Alzheimer’s disease.