Million-frames-per-second camera does sub-cellular bioimaging

December 1, 2010


A European consortium has developed theĀ Megaframe Imager, an ultrafast camera capable of recording images at one million frames per second.

It allows for cellular and sub-cellular imaging, neural imaging, biosensing, DNA and protein microarray scanning, automotive collision studies, and high-sensitivity astronomical observations.

The Megaframe Imager uses an extremely sensitive single photon avalanche diode (SPAD) device and custom-designed on-chip intelligence, in conjunction with DNA microarrays.

Experimental setup of the TIRF-SPAD imager

The researchers have demonstrated detection of viral DNA binding events using fluorescence lifetime imaging at the very low target concentrations relevant in biosensing applications, with acquisition times of less than 30 seconds.

Ref.: Fluorescence lifetime biosensing with DNA microarrays and a CMOS-SPAD imager, Biomedical Optics Express

Adapted from materials provided by NPL