Comments on: Most of the harmful mutations in people arose in the past 5,000 to 10,000 years http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years Accelerating Intelligence Thu, 20 Jun 2013 09:04:00 +0000 hourly 1 http://wordpress.org/?v=3.4.1 By: Cybernettr http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-66128 Cybernettr Sun, 09 Dec 2012 18:58:46 +0000 http://www.kurzweilai.net/?p=173061#comment-66128 If European Americans have a larger proportion of potentially harmful variants than African Americans than one wonders why they tend to live longer than blacks due to their lack of such diseases as Sickle Cell Anemia, etc. In the area of longevity, Asians tend to be at the top, whites in the middle and blacks at the bottom, wholly independent of environmental factors. If European Americans have a larger proportion of potentially harmful variants than African Americans than one wonders why they tend to live longer than blacks due to their lack of such diseases as Sickle Cell Anemia, etc. In the area of longevity, Asians tend to be at the top, whites in the middle and blacks at the bottom, wholly independent of environmental factors.

]]> By: Dayken http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-64479 Dayken Fri, 07 Dec 2012 19:53:21 +0000 http://www.kurzweilai.net/?p=173061#comment-64479 LOL yea people are people but you know they have make sound all fancy ans so on. ITs all human to me LOL yea people are people but you know they have make sound all fancy ans so on. ITs all human to me

]]> By: lamont http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-64358 lamont Fri, 07 Dec 2012 17:03:15 +0000 http://www.kurzweilai.net/?p=173061#comment-64358 This 5,000-10,000 time frame is somewhat consistent with one (young Earth) Creationist view on when human beings-in our present form- first populated the Earth. This 5,000-10,000 time frame is somewhat consistent with one (young Earth) Creationist view on when human beings-in our present form- first populated the Earth.

]]> By: Dan Robinson http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-63631 Dan Robinson Thu, 06 Dec 2012 20:08:14 +0000 http://www.kurzweilai.net/?p=173061#comment-63631 Dare I say it? As we develop larger scale health care, hospitals and such, less desirable genes have been helped to survive. Perhaps unfortunately, this seems to support the basic conservative paradigm, that we should all take care of ourselves, our descendants and maybe our siblings' descendents, and let the others take care of themselves. (But then we go on to supporting our ancsestors' descendants and eventually there's no place to draw the line.) We need (and always did) to take a new look at the differences between left and right. Of course we also need to have a realistic view on caring for our whole biosphere, on which we're all dependent. Dare I say it? As we develop larger scale health care, hospitals and such, less desirable genes have been helped to survive. Perhaps unfortunately, this seems to support the basic conservative paradigm, that we should all take care of ourselves, our descendants and maybe our siblings’ descendents, and let the others take care of themselves. (But then we go on to supporting our ancsestors’ descendants and eventually there’s no place to draw the line.) We need (and always did) to take a new look at the differences between left and right. Of course we also need to have a realistic view on caring for our whole biosphere, on which we’re all dependent.

]]> By: Mr.X http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-63362 Mr.X Thu, 06 Dec 2012 11:51:52 +0000 http://www.kurzweilai.net/?p=173061#comment-63362 "European Americans " There is no such thing.Just call it caucasian, like you always do;) But otherwise: Good news! “European Americans ”

There is no such thing.Just call it caucasian, like you always do;)

But otherwise: Good news!

]]> By: charles dufarle http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-63149 charles dufarle Thu, 06 Dec 2012 04:49:57 +0000 http://www.kurzweilai.net/?p=173061#comment-63149 I have only two words to say "Red Queen" I have only two words to say
“Red Queen”

]]> By: peter g http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-63005 peter g Thu, 06 Dec 2012 00:34:18 +0000 http://www.kurzweilai.net/?p=173061#comment-63005 it seems whites are more likely to get aggressive cancer outcomes from what i've read elsewhere this would confirm that it seems whites are more likely to get aggressive cancer outcomes from what i’ve read elsewhere

this would confirm that

]]> By: Editor http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-62429 Editor Wed, 05 Dec 2012 10:20:19 +0000 http://www.kurzweilai.net/?p=173061#comment-62429 Bri, I added the chart from the Nature article that seems most relevant to your questions, and you're right about the influence of migrations: As noted in a press release: http://www.washington.edu/news/2012/11/28/harmful-protein-coding-mutations-in-people-arose-largely-in-the-past-5000-to-10000-years/ : <blockquote>Larger populations, continuing to multiply by producing children, have more opportunities for new mutations to appear. The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago. During the Out of Africa migration of some early humans into Europe and beyond some 50,000 years past, a population bottleneck occurred: The number of humans plummeted, and the shrinking remnant became more genetically similar. Back then, mutations that were only slightly damaging had a greater probability of being carried from one generation to the next, Akey explained. “Those mutations don’t influence the ability to survive and reproduce,” he said. “The Out of Africa bottleneck led to inefficient purging of the less-harmful mutations.” His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes — those required to grow to adulthood and have offspring — and in genes linked to Mendelian, or single-mutation diseases. The study team also observed that the older the genetic variant, the less likely it was to be deleterious. ...Larger populations, continuing to multiply by producing children, have more opportunities for new mutations to appear. The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago. During the Out of Africa migration of some early humans into Europe and beyond some 50,000 years past, a population bottleneck occurred: The number of humans plummeted, and the shrinking remnant became more genetically similar. Back then, mutations that were only slightly damaging had a greater probability of being carried from one generation to the next, Akey explained. “Those mutations don’t influence the ability to survive and reproduce,” he said. “The Out of Africa bottleneck led to inefficient purging of the less-harmful mutations.” His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes — those required to grow to adulthood and have offspring — and in genes linked to Mendelian, or single-mutation diseases. The study team also observed that the older the genetic variant, the less likely it was to be deleterious. </blockquote> Bri, I added the chart from the Nature article that seems most relevant to your questions, and you’re right about the influence of migrations:

As noted in a press release: http://www.washington.edu/news/2012/11/28/harmful-protein-coding-mutations-in-people-arose-largely-in-the-past-5000-to-10000-years/ :

Larger populations, continuing to multiply by producing children, have more opportunities for new mutations to appear. The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago.

During the Out of Africa migration of some early humans into Europe and beyond some 50,000 years past, a population bottleneck occurred: The number of humans plummeted, and the shrinking remnant became more genetically similar. Back then, mutations that were only slightly damaging had a greater probability of being carried from one generation to the next, Akey explained.

“Those mutations don’t influence the ability to survive and reproduce,” he said. “The Out of Africa bottleneck led to inefficient purging of the less-harmful mutations.”

His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes — those required to grow to adulthood and have offspring — and in genes linked to Mendelian, or single-mutation diseases.

The study team also observed that the older the genetic variant, the less likely it was to be deleterious. …Larger populations, continuing to multiply by producing children, have more opportunities for new mutations to appear. The number of mutations thereby increases with accelerated population growth, such as the population explosion that began 5,115 years ago.

During the Out of Africa migration of some early humans into Europe and beyond some 50,000 years past, a population bottleneck occurred: The number of humans plummeted, and the shrinking remnant became more genetically similar. Back then, mutations that were only slightly damaging had a greater probability of being carried from one generation to the next, Akey explained.

“Those mutations don’t influence the ability to survive and reproduce,” he said. “The Out of Africa bottleneck led to inefficient purging of the less-harmful mutations.”

His group found that, compared to Africans, people of European descent had an excess of harmful mutations in essential genes — those required to grow to adulthood and have offspring — and in genes linked to Mendelian, or single-mutation diseases.

The study team also observed that the older the genetic variant, the less likely it was to be deleterious.

]]> By: Bri http://www.kurzweilai.net/most-of-the-harmful-mutations-in-people-arose-in-the-past-5000-to-10000-years/comment-page-1#comment-62186 Bri Wed, 05 Dec 2012 04:19:49 +0000 http://www.kurzweilai.net/?p=173061#comment-62186 It's a shame there wasn't mote information presented in the article. A nice graph of number of mutations over an extensive time period, say 100,000 years would be more illuminating. Population sizes and migration patterns in relation to mutations would also help. There is no doubt that bottlenecks have occured in migratory groups. I tend to think that migration probably has had the largest impact, but it's hard to say from such scant information. It’s a shame there wasn’t mote information presented in the article. A nice graph of number of mutations over an extensive time period, say 100,000 years would be more illuminating. Population sizes and migration patterns in relation to mutations would also help. There is no doubt that bottlenecks have occured in migratory groups. I tend to think that migration probably has had the largest impact, but it’s hard to say from such scant information.

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