Comments on: Nanoparticles against cellular aging

By: Ian Clarke

Ian Clarke — Tue, 09 Oct 2012 23:39:56 +0000

Thanks JC! Hopefully, one day we’ll all have nanoparticles coursing through us; repairing/destroying/improving at the cellular level.

“from link at bottom of article”

Yep, this was the “something obvious” I was missing! :-)

By: Editor

Editor — Tue, 09 Oct 2012 23:27:19 +0000

Thanks, added to the post (apologies for this oversight).

By: James

James — Tue, 09 Oct 2012 20:06:22 +0000

I know what you mean, but that’s actually just fine with me. We need WAY more funding for anti-aging research, and if that funding comes from people buying anti-wrinkle creams, (that actually work), then that’s just fine as far as I’m concerned. I know it says something about humanity that its wrinkles that will force them to do something, but hey, if I end up with rejuvenation technologies at the end of it, I don’t really care how we got there :)

By: JC

JC — Tue, 09 Oct 2012 20:03:10 +0000

“Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.” from link at bottom of article.

By: JC

JC — Tue, 09 Oct 2012 19:48:25 +0000

perhaps biomarker for senescence, p16Ink4a ?

http://www.nature.com/nature/journal/v479/n7372/full/nature10600.html

By: Ian Clarke

Ian Clarke — Tue, 09 Oct 2012 19:28:58 +0000

Unless I’m missing something obvious (always a strong possibility), it’s not clear how these nanoparticles are targeting. Does anyone know?

By: GatorALLin

GatorALLin — Tue, 09 Oct 2012 18:58:40 +0000

interesting how the update ends….. with focus on wrinkled skin…

who cares on that other stuff like getting Alzheimer’s… lets push this through due to the ability to reduce wrinkles…. watch out botox. I joke, but it would not surprise me if they get more funding or raise money faster due to the cosmetic values…vs. some of the health benefits…

By: Gabriel

Gabriel — Tue, 09 Oct 2012 18:40:37 +0000

But is it really a big deal? I’m thinking of the S-curve….maybe we’re not at the stage where the common man cheaply and very effectively get such therapies, but if it’s at the early point where only the rich can afford it, how effective can it be? In other words, we aren’t missing much (well, too much).

Unless of course, it’s already quite effective, in which case, you’re right…

By: Brian Roberts

Brian Roberts — Tue, 09 Oct 2012 18:25:40 +0000

Well said JC

By: JC

JC — Tue, 09 Oct 2012 16:45:56 +0000

Why should the “road to .. elimination therapies .. for aging cells be long”? We know many substances that trigger cell suicide. They now seem to have a delivery vehicle that has decent selectivity for senescent cells. I suspect that such therapies will be available within months, outside the US and for ‘well connected’ clientele.