New tool reveals molecular signature of cancer and HIV

October 28, 2004 | Source: KurzweilAI

Scientists have designed a new molecular tool, dubbed “LigAmp,” to pinpoint DNA mutations among thousands of cells, the equivalent of searching for a single typo in an entire library of books. Preliminary studies in a small number of cell lines and body fluids show the ultra-sensitive test may help detect microscopic cancer and HIV drug resistance.

The test works by creating a molecular “magnet” with an affinity for the DNA mistake, also known as a point mutation. If the mutation is found, the magnet binds to it and inserts a bacterial gene. The bacterial gene serves as a red flag and produces a fluorescent color visible to powerful computer programs.

Johns Hopkins Medical Institutions news release