January 2, 2004
Shedding light on why drastically restricting calorie intake prolongs life span in some organisms, MIT researchers have found that lowering the level of the common NADH coenzyme activates an anti-aging gene in yeast.
MIT Biology Professor Leonard P. Guarente discovered in 2000 that calorie restriction activates the silenced information regulator (SIR2) gene,
which makes a protein called Sir2 that is normally activated by the coenzyme molecule NAD. Guarente has… read more