Recently Added Most commented

Deep learning applied to drug discovery and repurposing

May 27, 2016

Deep neural networks for drug discovery (credit: Insilico Medicine, Inc.)

Scientists from Insilico Medicine, Inc. have trained deep neural networks (DNNs) to predict the potential therapeutic uses of 678 drugs, using gene-expression data obtained from high-throughput experiments on human cell lines from Broad Institute’s LINCS databases and NIH MeSH databases.

The supervised deep-learning drug-discovery engine used the properties of small molecules, transcriptional data, and literature to predict efficacy, toxicity, tissue-specificity, and heterogeneity of response.

“We used LINCSread more

Automated top-down design technique simplifies creation of DNA origami nanostructures

Nanoparticles for drug delivery and cell targeting, nanoscale robots, custom-tailored optical devices, and DNA as a storage medium are among the possible applications
May 27, 2016

The boldfaced line, known as a spanning tree, follows the desired geometric shape, touching each vertex just once. A spanning tree algorithm is used in the new DNA origami method to map out the proper routing path for the DNA strand. (credit: Public Domain)

MIT, Baylor College of Medicine, and Arizona State University Biodesign Institute researchers have developed a radical new top-down DNA origami* design method based on a computer algorithm that allows for creating designs for DNA nanostructures by simply inputting a target shape.

DNA origami (using DNA to design and build geometric structures) has already proven wildly successful in creating myriad forms in 2- and… read more

Triggering the protein that programs cancer cells to kill themselves

May 24, 2016


WEHI | Apoptosis

Researchers at the Walter and Eliza Hall Institute in Australia have discovered a new way to trigger cell death that could lead to drugs to treat cancer and autoimmune disease.

Programmed cell death (a.k.a. apoptosis) is a natural process that removes unwanted cells from the body. Failure of apoptosis can allow cancer cells to grow unchecked or immune cells to inappropriately… read more

Diamonds closer to becoming ideal power semiconductors

May 24, 2016

A diode array on a natural single crystalline diamond plate. (The image looks blurred due to light scattering by the array of small pads on top of the diamond plate.) Inset shows the deposited anode metal on top of heavy doped silicon nanomembrane, which is bonded to natural single crystalline diamond. (credit: Jung-Hun Seo)

Researchers have developed a new method for doping (integrating elements to change a semiconductor’s properties) single crystals of diamond with boron at relatively low temperatures, without degradation.

Diamonds have properties that could make them ideal semiconductors for power electronics. They can handle high voltages and power, and electrical currents also flow through diamonds quickly, meaning the material would make for energy-efficient devices. And they are thermally conductive, which means… read more

No longer ‘junk DNA’ — shedding light on the ‘dark matter’ of the genome

A new tool called "LIGR-Seq" enables scientists to explore in depth what non-coding RNAs actually do in human cells
May 23, 2016

A plot of human RNA-RNA interactions detected by ligr-seq (credit: University of Toronto)

What used to be dismissed by many as “junk DNA” has now become vitally important, as accelerating genomic data points to the importance of non-coding RNAs (ncRNAs) — a genome’s messages that do not specifically code for proteins — in development and disease.

But our progress in understanding these molecules has been slow because of the lack of technologies that allow for systematic mapping of their functions.… read more

Cancer-patient big data can save lives if shared globally

May 23, 2016

Data-sharing vision as facilitated by GA4GH through its working groups (credit: GA4GH)

Sharing genetic information from millions of cancer patients around the world could revolutionize cancer prevention and care, according to a paper in Nature Medicine by the Cancer Task Team of the Global Alliance for Genomics and Health (GA4GH).

Hospitals, laboratories and research facilities around the world hold huge amounts of this data from cancer patients, but it’s currently held in isolated “silos” that don’t talk to each other, according to… read more

Gene helps prevent heart attack, stroke; may also block effects of aging

May turn out to be the "fountain-of-youth gene," say researchers
May 20, 2016

This is an atherosclerotic lesion. Such lesions can rupture and cause heart attacks and strokes. (credit: UVA School of Medicine)

University of Virginia School of Medicine have discovered that a gene called Oct4 — which scientific dogma insists is inactive in adults — actually plays a vital role in preventing ruptured atherosclerotic plaques inside blood vessels, the underlying cause of most heart attacks and strokes.

The researchers found that Oct4 controls the conversion of smooth muscle cells into protective fibrous “caps” inside plaques, making the plaques less likely to… read more

British researchers, Google design modular shape-shifting mobile devices

May 20, 2016

Cubimorph & ARA ft

British researchers and Google have independently developed revolutionary concepts for Lego-like modular interactive mobile devices.

The British team’s design, called Cubimorph, is constructed of a chain of cubes. It has touchscreens on each of the six module faces and uses a hinge-mounted turntable mechanism to self-reconfigure in the user’s hand. One example: a mobile phone that can transform into a console when a user launches a game.… read more

Robots learn to cut through clutter

Exploit creative "superhuman" capabilities
May 20, 2016

New software developed by Carnegie Mellon University helps mobile robots deal efficiently with clutter, whether it is in the back of a refrigerator or on the surface of the moon. (credit: Carnegie Mellon University Personal Robotics Lab)

Carnegie Mellon University roboticists have developed an algorithm that helps robots cope with a cluttered world.

Robots are adept at picking up an object in a specified place (such as in a factory assembly line) and putting it down at another specified place (known as “pick-and-place,” or P&P, processes). But homes and other planets, for example, are a special challenge for robots.

When a person reaches… read more

Using animal training techniques to teach robots household chores

May 18, 2016

Virtual environments in which trainers gave directions to robot dog. (credit: Washington State University)

Researchers at Washington State University are using ideas from animal training to help non-expert users teach robots how to do desired tasks.

As robots become more pervasive in society, humans will want them to do chores like cleaning house or cooking. But to get a robot started on a task, people who aren’t computer programmers will have to give it instructions. “So we needed to provide a… read more

Self-healing, flexible electronic material restores functions after multiple breaks

May 18, 2016


A new electronic material created by an international team headed by Penn State scientists can heal all its functions automatically, even after breaking multiple times. The new material could improve the durability of wearable electronics.

Electronic materials have been a major stumbling block for the advance of flexible electronics because existing materials do not function well after breaking and healing.

“Wearable and bendable electronics are subject to mechanical… read more

A simple home urine test could scan for diseases

May 18, 2016

Prototype urinalysis device (credit: Gennifer T. Smith et al./Lab On A Chip)

Stanford University School of Engineering | This easy-to-assemble black box is part of an experimental urinalysis testing system designed by Stanford engineers. The black box is meant to enable a smartphone camera to capture video that accurately analyzes color changes in a standard paper dipstick to detect conditions of medical interest.

Two Stanford University electrical engineers have designed a simple new low-cost, portable urinalysis device that could allow patients… read more

IBM scientists achieve storage-memory breakthrough with PCM

PCM combines speed of DRAM and non-volatility of flash, providing fast, easy storage for the exponential growth of data from mobile devices, the Internet of Things, and cloud computing
May 16, 2016

For the first time, scientists at IBM Research have demonstrated reliably storing 3 bits of data per cell using a relatively new memory technology known as phase-change memory (PCM). In this photo, the experimental multi-bit PCM chip used by IBM scientists is connected to a standard integrated circuit board. The chip consists of a 2 × 2 Mcell array with a 4- bank interleaved architecture. The memory array size is 2 × 1000 μm × 800 μm. The PCM cells are based on doped-chalcogenide alloy and were integrated into the prototype chip serving as a characterization vehicle in 90 nm CMOS baseline technology. (credit: IBM Research)

Scientists at IBM Research have demonstrated — for the first time (today, May 17), at the IEEE International Memory Workshop in Paris — reliably storing 3 bits of data per cell in a 64k-cell array in a memory chip*, using a relatively new memory technology known as phase-change memory (PCM). Previously, scientists at IBM and elsewhere successfully demonstrated the ability to store only 1 bit per cell in… read more

Machine learning outperforms physicists in experiment

May 16, 2016

The experiment, featuring the small red glow of a BEC trapped in infrared laser beams. (credit: Stuart Hay, ANU)

Australian physicists have used an online optimization process based on machine learning to produce effective Bose-Einstein condensates (BECs) in a fraction of the time it would normally take the researchers.

A BEC is a state of matter of a dilute gas of atoms trapped in a laser beam and cooled to temperatures just above absolute zero. BECs are extremely sensitive to external disturbances, which makes them ideal for research… read more

Ingestible ‘origami robot’ lets doctors operate on a patient remotely

May 16, 2016

An "origami robot" unfolds itself from an ingestible capsule, and can be used to perform operations in the body (credit: Melanie Gonick/MIT)

MIT researchers and associates have developed a tiny “origami robot” that can unfold itself from a swallowed capsule and, steered by a physician via an external magnetic field, crawl across the stomach wall to operate on a patient. For example, it can remove a swallowed button battery or patch a wound.

Every year, 3,500 swallowed button batteries are reported in the U.S. alone. Frequently, the batteries are… read more

close and return to Home