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Nanocasting custom-shaped metal nanoparticles in DNA molds

DNA-based programmable assembly to form precise 3D nanomaterials for disease detection, environmental testing, electronics, and beyond
October 13, 2014

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Extending 3D printing of metals to the nanoscale, researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have developed a new method of forming 3D metal nanoparticles in prescribed shapes and dimensions using DNA as a construction mold.

The ability to mold inorganic nanoparticles out of materials such as gold and silver in precisely designed 3D shapes is a significant breakthrough that has the potential to… read more

Advances in ‘laser solid forming’ to produce 3D-printed metallic parts

October 13, 2014

Inconel 718 nickel-chromium alloy casing for an aircraft engine by hybrid manufacturing with LSF and casting (credit: Weidong Huang and Xin Lin/3D Printing and Additive Manufacturing)

Researchers Weidong Huang and Lin Xin from China’s Northwestern Polytechnical University describe their progress with 3D-printed metallic parts, using laser solid forming (LSF) technology, in an open-access (until Nov. 9) review article in 3D Printing and Additive Manufacturing, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

The authors review research advances toward the goal of developing LSF — an additive manufacturing technique that uses laser… read more

High-speed fluorescence for 1,000-times-faster LEDs

Future uses include telecommunication lasers and as single-photon sources for quantum cryptography
October 13, 2014

Plasmonics_Nanocube

Duke University researchers have made fluorescent molecules emit photons of light 1,000 times faster than with previous designs — a speed record, and a step toward realizing superfast light-emitting diodes (LEDs) for nanophotonic devices, such as telecommunication lasers and as single-photon sources for quantum cryptography.

The 2014 Nobel Prize in Physics was awarded for the discovery 20 years ago of how to make blue LEDs, leading… read more

The Nobel Prize in Chemistry 2014: beyond the diffraction limit in microscopy

October 10, 2014

The principle of single-molecule microscopy (credit: Johan Jarnestad /The Royal Swedish Academy of Sciences)

The Royal Swedish Academy of Sciences has awarded the Nobel Prize in Chemistry for 2014 to three scientists for the development of super-resolved fluorescence microscopy: Eric Betzig, Janelia Research Campus, Howard Hughes Medical Institute; Stefan W. Hell, Max Planck Institute for Biophysical Chemistry and German Cancer Research Center, Heidelberg;  and William E. Moerner, Stanford University.

The Prize amount: SEK 8 million (US$1.1 million or… read more

Heated nanoparticles trigger immune systems deactivated by cancer

October 10, 2014

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Researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center have developed a method to use heat with nanoparticles to wake up the immune system so it recognizes and attacks invading cancer cells, according to Steve Fiering, PhD, Norris Cotton Cancer Center researcher and professor of Microbiology and Immunology, and of Genetics at the Geisel School ofread more

High-speed drug screening

October 9, 2014

This schematic drawing shows a new system that can rapidly and automatically inject zebrafish with drugs and then image them to see the drug effects. (Credit: MIT)

MIT engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and DNA, to human patients.

In a study appearing in the journal Integrative Biology, the researchers used this technology to identify materials that can efficiently deliver RNA to zebrafish and also to… read more

Animated 3D movies show cells in action over time

October 9, 2014

A screen from LEVER 3-D, software that can produce a 3D rendering of microscope images of cells and animate it through time to show their multiplication and movement (credit: Drexel University)

Drexel University researchers have developed software and hardware that will enable biologists to use 3D glasses in a home-theater-like lab to better track and study the movement and multiplication of cells.

Their goal is to enhance the current visual data that these scientists are working with so that it’s easier to identify changes in cells over time — information that is key to studying the abnormal cell proliferation that… read more

New ‘lab-on-a-chip’ could revolutionize early diagnosis of cancer

October 8, 2014

(Credit: University of Kansas Medical Center)

A new miniaturized biomedical “lab-on-a-chip” testing device for exosomes — molecular messengers between cells — promises faster, earlier, less-invasive diagnosis of cancer, according to its developers at the University of Kansas Medical Center and the University of Kansas Cancer Center.

“A lab-on-a-chip shrinks the pipettes, test tubes and analysis instruments of a modern chemistry lab onto a microchip-sized wafer,” explained Yong Zeng, assistant… read more

Quantum robots will be more creative, faster, smarter, say researchers

October 8, 2014

The theoretical work has focused on using quantum computing to accelerate the machine learning. (Credit: SINC)

Quantum computing should be applied to robots, automatons, and other agents that use AI to make them more creative and to learn and respond faster than conventional robots, researchers from the Complutense University of Madrid (UCM) and the University of Innsbruck (Austria) recommend.

In a study in the journal ‘Physical Review X’ modeling the use of quantum physics in future robots (and other agents), they demonstrate that… read more

‘Smart’ bandage glows to measure oxygenation

October 8, 2014

The transparent liquid bandage displays a quantitative, oxygenation-sensitive colormap that can be easily acquired using a simple camera or smartphone (Credit: Li/Wellman Center for Photomedicine)

Inspired by a desire to help wounded soldiers, a team of researchers has created a paint-on, see-through, “smart” bandage that glows to indicate a wound’s tissue oxygenation concentration.

Oxygen plays a critical role in healing, so mapping these levels in severe wounds and burns can help to significantly improve the success of surgeries to restore limbs and physical functions.

The development was led by Assistant Professor Conor L.… read more

The signature of aging in the brain

Cognitive decline may be related to one's "immunological age"
October 7, 2014

Immunofluorescence microscope image of the choroid plexus. Epithelial cells are in green and chemokine proteins (CXCL10) are in red (credit: Weizmann Institute of Science)

Weizmann Institute of Science researchers have found evidence of a unique “signature” that may be the “missing link” between cognitive decline and aging and that may in the future lead to treatments that can slow or reverse cognitive decline in older people, according to Prof. Michal Schwartz of the Department of Neurobiology and Ido Amit of the Department of Immunology.

Until a decade ago, scientific dogma held that the blood-brain… read more

Supercapacitors from ‘crumpled graphene’ could power flexible electronic devices

October 7, 2014

To form the crumpled graphene, a sheet of polymer material is stretched in both dimensions, then graphene paper is bonded to it. When the polymer is released in one direction, the graphene forms pleats, as shown in the bottom left image, taken with a scanning electron microscope (SEM). Then, when released in the other direction, it forms a chaotic crumpled pattern (top left). At top right, an SEM image shows the material in a partially crumpled state. At bottom right, SEM image of a piece that has been crumpled and then flattened out (Credit: Image courtesy of the researchers)

MIT researchers have found that crumpling a piece of graphene “paper” — a material formed by bonding together layers of the two-dimensional form of carbon — can yield new properties that could be useful for creating extremely stretchable supercapacitors to store energy for flexible electronic devices.

The finding is reported in the journal Scientific Reports (open access) by MIT’s Xuanhe Zhao, an assistant professor of mechanical engineering and civil and… read more

How to turn your Android phone into a cosmic ray detector

October 7, 2014

Cell-phone-camera image showing evidence of a cosmic ray particle hit (surrounded by sensor noise) (credit: Justin Vandenbroucke)

An Android app (iPhone app planned) that transforms your cell phone into a cosmic-ray particle detector has been created by Justin Vandenbroucke, a University of Wisconsin-Madison assistant professor of physics and a researcher at the Wisconsin IceCube Particle Astrophysics Center (WIPAC).

“It uses the same principles as these very large experiments,” he says.

Cosmic rays are energetic subatomic particles created, scientists think, in cosmic accelerators like black holes… read more

2014 Nobel Prize in Physiology or Medicine awarded for ‘inner GPS’ research

Robotic-vision expert extends this research to intelligent robot navigation
October 6, 2014

Grid cells, together with other cells in the entorhinal cortex that recognize the direction of the head of the animal and the border of the room, form networks with<br />
the place cells in the hippocampus. This circuitry constitutes a comprehensive positioning system in the brain that appears to have components similar to those of the rat brain. (Credit:  Mattias Karlén/The Nobel Committee for Physiology or Medicine)

The 2014 Nobel Prize in Physiology or Medicine has just been awarded to John O´Keefe and jointly to May-Britt Moser and Edvard I. Moser for the discovery of a positioning system in the brain.

This “inner GPS” makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function. According to the Nobel Committee for Physiology or Medicine:

John O’Keefe discovered,… read more

Green-tea-based nanocarrier kills cancer cells more effectively

October 6, 2014

Green-tea based druig carrier

A drug-delivery system that may kill cancer cells more efficiently has been developed by Singapore researchers, using an antioxidant ingredient of green tea.

A key ingredient in green tea, epigallocatechin gallate (EGCG), is an antioxidant known to have therapeutic applications in the treatment of many disorders, including cancer. A*STAR’s Institute of Bioengineering and Nanotechnology (IBN) researchers have now engineered nanocarriers using EGCG that they say can deliver drugs and kill cancer… read more

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