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Protein ‘filmed’ while unfolding at atomic resolution

May contribute to a better understanding of how proteins misfold during illness
February 13, 2013

“Snapshot” of the unfolding of the CylR2 protein from Enterococcus faecalis. If the protein is cooled from 25°C to -16°C, it successively breaks down into its two identical subunits. The latter are initially stable, but at -16°C they form an instable, dynamic protein form, which plays a key role in folding. (Credit: Zweckstetter/Max Planck Institute for Biophysical Chemistry & German Center for Neurodegenerative Diseases)

Researchers at the Max Planck Institute for Biophysical Chemistry and the German Center for Neurodegenerative Diseases in Göttingen — in collaboration with Polish colleagues — have now “filmed” how a protein gradually unfolds for the first time.

By combining low temperatures and NMR spectroscopy, the scientists visualized seven intermediate forms of the CylR2 protein while cooling it down from 25°C to – 16°C.… read more

Topics: Biotech

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Imaging fish larvae in 3D could aid drug development

February 13, 2013

mit_3d_fish

Zebrafish larvae — tiny, transparent and fast-growing vertebrates — are widely used to study development and disease. However, visually examining the larvae for variations caused by drugs or genetic mutations is an imprecise, painstaking and time-consuming process.

Engineers at MIT have now built an automated system that can rapidly produce 3D, micron-resolution images of thousands of zebrafish larvae and precisely analyze their physical traits. The… read more

Topics: Biotech | Nanotech/Materials Science

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‘Artificial atoms’ allow for sensing magnetic fields of individual cells

February 13, 2013

Artist's impression of nanomanipulation of an artificial atom (credit: ICFO)

Researchers in Spain and Australia have developed a new technique that similar to MRI but with the high resolution and sensitivity need to scan individual cells.

The researchers, from the Institute of Photonic Sciences (ICFO), in collaboration with the CSIC and Macquarie University in Australia, are led by ICFO Prof. Romain Quidant. They used “artificial atoms” — diamond nanoparticles doped with nitrogen impurity — to probe… read more

Topics: Biomed/Longevity | Nanotech/Materials Science

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Welcome to the malware-industrial complex

February 13, 2013

(Credit: iStockphoto)

The U.S. government is developing new computer weapons and driving a black market in “zero-day” bugs. The result could be a more dangerous Web for everyone, says MIT Technology Review.

A freshly discovered weakness in a popular piece of software, known in the trade as a “zero-day” vulnerability, can be cashed in for much more than a reputation boost and some free drinks at the bar. Information about such flaws can command prices in… read more

Topics: Internet/Telecom | Survival/Defense

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Portable peer review

Author-pays service cuts down on redundant reviews
February 13, 2013

rubriq

Researchers waiting for their manuscript to emerge from multiple rounds of peer review as it bounces from journal to journal can easily get frustrated at the inefficiencies of the system. Soon, they may have another option: paying for a fast, independent peer review that could travel with the paper from one journal to another, and eliminate redundant peer reviews, Nature News reports.

The concept comes from a… read more

Topics: Innovation/Entrepreneurship | Social/Ethical/Legal

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Spy-camera robot penguins infiltrate bird colonies

February 13, 2013

penguinbbc_610x329

A BBC documentary team unleashed 50 spycams into penguin colonies, including cameras that served as eyes for robotic penguins, to capture stunning close-up footage of the unusual birds, CNET reports.

“Penguins: Spy in the Huddle” documents nearly a year hanging out with penguins through the surrogate eyes of 50 different spycams. Some of the spycams were disguised as chunks of snow or small boulders, but… read more

Topics: AI/Robotics | Entertainment/New Media

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3D printing: ‘potential to revolutionize the way we make almost everything’ — President Obama

February 13, 2013

(Credit: White House)

In his State of the Union address Tuesday night, U.S. President Barack Obama noted that “Our first priority is making America a magnet for new jobs and manufacturing. After shedding jobs for more than 10 years, our manufacturers have added about 500,000 jobs over the past three.

“Caterpillar is bringing jobs back from Japan. Ford is bringing jobs back from Mexico. After locating plants in other countries… read more

Topics: Nanotech/Materials Science | Social/Ethical/Legal

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Injection-free vaccination

Delivering live vaccines without a refrigerator
February 12, 2013

Scientists at King's have demonstrated the ability to deliver a dried live vaccine to the skin without a traditional needle, and shown for the first time that this technique is powerful enough to enable specialised immune cells in the skin to kick-start the immunising properties of the vaccine.

Scientists at King’s College London have demonstrated the ability to deliver a dried live vaccine to the skin without a traditional needle, and shown for the first time that this technique is powerful enough to enable specialized immune cells in the skin to kick-start the immunizing properties of the vaccine.

Funded by the Bill & Melinda Gates Foundation, researchers say that although it is an… read more

Topics: Biomed/Longevity

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Is the ozone layer on the road to recovery?

February 12, 2013

Total polar ozone in the northern and southern hemispheres as measured by various instruments. The blue line depicts projections based on the Chemistry Climate Model E39CA. The total ozone reached its lowest levels in both hemispheres in the late 1990s, and it is expected to increase in the coming years.(Credit: ESA/DLR/Eumetsat/NASA/WMO/GAW)

Satellites show that the recent ozone hole over Antarctica was the smallest seen in the past decade. Long-term observations also reveal that Earth’s ozone has been strengthening following international agreements to protect this vital layer of the atmosphere.

According to the ozone sensor on Europe’s MetOp weather satellite, the hole over Antarctica in 2012 was the smallest in the last 10 years.

Since the… read more

Topics: Environment/Climate | Space

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Can interacting with avatars reduce depression?

February 12, 2013

Depression

A preliminary study by researchers at Case Western Reserve University suggests that depression symptoms may be significantly reduced when 18- to 25-year-olds interact with computerized avatars — virtual 3D images of a healthcare provider like a nurse practitioner or physician — as a way to rehearse office visits ahead of time and learn self-management skills.

At this age, a majority of young people do not… read more

Topics: Cognitive Science/Neuroscience | VR/Augmented Reality/Computer Graphics

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How ‘bullet time’ will revolutionize exascale computing

The filming technique used in The Matrix will change the way we access the huge computer simulations of the future, say computer scientists
February 12, 2013

( Credit: Warner Bros. Pictures)

The exascale computing era is almost upon us and computer scientists are already running into difficulties. 1 exaflop is 10^18 floating point operations per second, that’s a thousand petaflops. The current trajectory of computer science should produce this kind of  capability by 2018 or so.

How do humans access and make sense of the exascale data sets?

The answer, of course, is to find some way to compress… read more

Topics: Computers/Infotech/UI | VR/Augmented Reality/Computer Graphics

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Self-assembling molecules offer new clues on life’s possible origin

A pair of RNA-like molecules can spontaneously assemble into gene-length chains
February 12, 2013

rna_lite_tapas

Billions of years ago, related molecules may have created a rudimentary form of genetic information that eventually led to the evolution of RNA and life itself, the researchers say. Although it’s likely to be difficult, if not impossible, to prove whether similar proto-RNAs were present at the dawn of life, the researchers are working to see if the proto-RNAs can indeed faithfully encode information and evolve… read more

Topics: Synthetic Biology

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Biofeedback mobile app

February 12, 2013

lg-icon-biozen2

The Department of Defense has released an Android smartphone app to help service members use the therapeutic benefits of biofeedback.

BioZen, a mobile app from the Defense Department’s National Center for Telehealth and Technology (T2), uses Bluetooth-coupled sensors to show the user their physical level of relaxation.

It is the first portable, low-cost method for clinicians and patients to use biofeedback in… read more

Topics: Cognitive Science/Neuroscience

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Project Holodeck hands-on demo and interview with director Nathan Burba

February 12, 2013

project_holodeck

Recently I got a chance to meet up with Project Holodeck director Nathan Burba, Ben Lang writes at Road to VR.

Not only did we sit down for a detailed interview, but I was also fortunate enough to get a hands-on demo of the system. Project Holodeck is an immersive virtual reality multiplayer platform. …

Project Holodeck, which will actually be using the Oculus… read more

Topics: Entertainment/New Media | VR/Augmented Reality/Computer Graphics

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Microscopic 3D printing

February 11, 2013

Nanoscribe_Hellcat 2013_001

Nanoscribe GmbH, a spin-off of Karlsruhe Institute of Technology (KIT), has developed the world’s fastest 3D printer of micro- and nanostructures, the German company claims.

With this printer, three-dimensional objects, often smaller than the diameter of a human hair, can be manufactured with minimum time consumption and maximum resolution. The printer is based on a novel laser lithography method.

Nanoscribe systems are… read more

Topics: Nanotech/Materials Science

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