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Biocompatible silicon developed

July 14, 2001

Silicon can be developed into a biocompatible and biodegradable material that could lead to smaller, smarter and more-interactive implants in the human body. The secret: “porous” silicon ­– bulk silicon that has been deliberately riddled with nanometer-sized holes.
Rather than having to shield a silicon-based device from body tissues and the bloodstream, it is now theoretically possible to construct silicon-based devices that are genuinely “bioactive.”

The surface of a… read more

Biocompatible graphene transistor array reads cellular signals

December 5, 2011

This combination of optical microscopy and fluorescence imaging shows a layer of biological cells covering a graphene-based transistor array. The experimental device, created by scientists from the Technische Universitaet Muenchen and the Juelich Research Center, is the first of its kind to prove capable of recording signals generated by living cells, with good spatial and temporal resolution. With this demonstration, the researchers have opened the way to further investigation of the feasibility of using graphene-based bioelectronics for potential future applications such as neuroprosthetic implants in the brain, the eye, or the ear (credit: Copyright TU Muenchen)

Researchers at Technische Universitaet Muenchen (TUM) and the Juelich Research Center have demonstrated, for the first time, a graphene-based transistor array that is compatible with living biological cells and capable of recording the electrical signals they generate.

Bioelectronic applications have been proposed that would place sensors or even actuators inside a person’s brain, eye, or ear to help compensate for neural damage. Pioneering research in this direction… read more

Biocompatible carbon nanotubes developed

July 27, 2006

University of California at Berkeley and Howard Hughes Medical Institute researchers have developed a means of making CNTs biocompatible by coating them with synthetic synthetic glycopolymers that mimic mucin, the substance on cell surfaces that serves as a lubricant.

They were able to customize the coatings so that carbon nanotubes could be induced to bind only to the surfaces of specific types of cells via ligand receptors. To do… read more

Biocompatibility established for therapeutic nanoparticles

April 21, 2011

Investigators at the Stanford University School of Medicine have shown that gold-centered spheres smaller than viruses are safe when administered by two alternative routes in a mouse study.

The study is the first-ever successful demonstration of the safety of a new class of agents: tiny gold balls that have been coated with materials designed to be detected with very high sensitivity, then encased in see-through silica… read more

Biochip-based device for cell analysis

June 1, 2012

This is an assembled flow cytometry chip with size comparable to a US quarter (credit: Tony Jun Huang, Penn State)

Inexpensive, portable devices that can rapidly screen cells for leukemia or HIV may soon be possible thanks to a chip that can produce 3D focusing of a stream of cells, according to researchers.

“HIV is diagnosed based on counting CD4 cells,” said Tony Jun Huang, associate professor of engineering science and mechanics, Penn State. “Ninety percent of the diagnoses are done using flow cytometry.”

Huang and… read more

Biochip tracks influenza in real time

Could be carried by anyone in first-aid kit
June 11, 2012


Brown University researchers have created a reliable, fast flu-detection test that can be carried in a first-aid kit.

The novel prototype device isolates influenza RNA using a combination of magnetics and microfluidics, then amplifies and detects probes bound to the RNA. The technology could lead to real-time tracking of influenza.

In April 2009, the world took notice as reports surfaced of a virus in… read more

Biochip spots single viruses

October 21, 2004

Environmental sensors and handheld devices that quickly and easily detect and identify individual viruses would provide early warning of infections in individuals, the spread of disease in populations, and biological weapons attacks.

Harvard University researchers led by Charles Lieber, a professor of chemistry, have built a detector from nanowire transistors that can identify individual virus particles in real time in unpurified samples. The prototype uses antibody proteins attached to… read more

Biochip puts it all together

December 4, 2003

Researchers from Arizona State University have fabricated a lab-on-a-chip that can detect and analyze microorganisms and chemicals and is very cheap to produce.

The chip could eventually be used in portable devices that do genetic analysis, environmental testing, and biological warfare agent detection in the field.

What sets the chip apart from other prototype biochips is that it carries out all the work needed to prepare a sample… read more

Biochip Mimics The Body To Reveal Toxicity Of Industrial Compounds

December 18, 2007

A reseach team has developed two biochips that combine to reveal the potential toxicity of chemicals and drug candidates on various organs in the human body, and whether those compounds will become toxic when metabolized in the body, all in one experiment without the use of live animals.

The technology could have applications in personalized medicine. The two chips could someday be used to determine the levels and combinations… read more

Biochip makes droplet test tubes

March 8, 2004

A programmable biochip that uses an array of electrodes to place water droplets on a surface, insert substances into the droplets, and move and merge the droplets, with no moving parts, could eventually be miniaturized and incorporated into portable medical, biological and chemical diagnostic devices.

These can form the core of versatile, automated, microscale devices for performing chemical and biological assays at or near the point of care.

‘Biochemiresistor’ sensor is fast, super-sensitive

June 1, 2012


A new class of biosensor that can detect exceptionally small traces of contaminants in liquids in just 40 minutes has been developed by a University of New South Wales (UNSW)-led team of researchers.

Known as a biochemiresistor, it meets a long-standing challenge to create a sensor that is both super-sensitive to the presence of chemical compounds and responds quickly.

It has countless potential uses… read more

Biochemical clues to long lifespan revealed

February 20, 2004

Researchers at Children’s Hospital Boston have found that longer life results, at least in part, from biochemical interactions that boost cells’ ability to resist environmental stresses while inhibiting them from committing suicide.

The team found that the Sir2 gene regulates a group of proteins known as FOXO transcription factors. These proteins have been linked with longevity; they control the expression of genes that regulate cell suicide, and also enable… read more

BioCDs could allow for rapid disease tests

May 20, 2004

While-you-wait medical tests that screen patients for thousands of disease markers by detecting proteins could be possible with “BioCDs” –compact-disc technology patented by a team of Purdue University scientists led by physicist David D. Nolte.

CDs ordinarily store digital information as billions of tiny “pits” in their surface. The test transforms these into miniature test tubes that can hold a trace quantity of a chemical that reacts to a… read more

Biobutanol: Next generation of biofuels

May 24, 2011

Scientists at the SUNY College of Environmental Science and Forestry (ESF) are researching ways to turn wood into sustainable biobutanol.

Biobutanol is one of a handful of fuels that can be produced from wood sugars; the specific fuel that is produced depends on what kind of organism is used to ferment the sugar.

Biobutanol offers several advantages over the ethanol that is commonly mixed… read more


May 21, 2003

Some tiny new machines may be biomedical devices that could deliver drugs to precise targets inside your body, or carry out internal repairs on the spot. Nanotechnologists are working at the level of individual atoms and molecules, either to create new materials with astonishing properties, or to build miniscule machines. Right now, prototypes of these miracle machines exist. Some are made of natural molecules; others are hybrids of molecules and… read more

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