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Travelers to Mars risk leukemia cancer, weakened immune function from radiation, NASA-funded study finds

March 27, 2017

The spleen from a mouse exposed to a mission-relevant dose (20 cGy, 1 GeV/n) of iron ions (bottom) was ~ 30 times the normal volume compared with the spleen (top) from a control mouse. (credit: C Rodman et al./Leukemia)

Radiation encountered in deep space travel may increase the risk of leukemia cancer in humans traveling to Mars, NASA-funded researchers at the Wake Forest Institute for Regenerative Medicine and colleagues have found, using mice transplanted with human stem cells.

“Our results are troubling because they show radiation exposure could potentially increase the risk of leukemia,” said Christopher Porada, Ph.D., associate professor of regenerative medicine and… read more

Scientists reverse aging in mice by repairing damaged DNA

Could lead to an anti-aging drug that counters damage from old age, cancer, and radiation
March 26, 2017

Disarming a rogue agent: When the NAD molecule (red), binds to the DBC1 protein (beige), it prevents DBC1 from attaching to and incapacitating a protein critical for DNA repair. (credit: David Sinclair)

A research team led by Harvard Medical School professor of genetics David Sinclair, PhD, has made a discovery that could lead to a revolutionary new drug that allows cells to repair DNA damaged by aging, cancer, and radiation.

In a paper published in the journal Science on Friday (March 24), the scientists identified a critical step in the molecular process related to DNA damage.… read more

Mayo Clinic discovers high-intensity aerobic training can reverse aging

March 24, 2017

A Mayo Clinic study found high-intensity aerobic exercise may reverse aging (credit: Flickr user Global Panorama via Creative Commons license)

A Mayo Clinic study says the best training for adults is high-intensity aerobic exercise, which they believe can reverse some cellular aspects of aging.

Mayo researchers compared 12 weeks of high-intensity interval training (workouts in which you alternate periods of high-intensity exercise with low-intensity recovery periods), resistance training, and combined training. While all three enhanced insulin sensitivity and lean mass, only high-intensity interval training and combined training improved aerobic capacity and… read more

Whole-body vibration may be as effective as regular exercise

March 16, 2017

Hate treadmills? The Tranquility Pod uses “pleasant sound, gentle vibration, and soothing light to transport the body, mind, and spirit to a tranquil state of relaxation” --- and maybe lose weight (and $30,000). (credit: Hammacher Schlemmer)

If you’re overweight and find it challenging to exercise regularly, now there’s good news: A less strenuous form of exercise known as whole-body vibration (WBV) can mimic the muscle and bone health benefits of regular exercise — at least in mice — according to a new study published in the Endocrine Society’s journal Endocrinology.

Lack of exercise is contributing to the obesity and diabetes epidemics, according to the researchers. These… read more

First nanoengineered retinal implant could help the blind regain functional vision

Nanowires provide higher resolution than anything achieved by other devices --- closer to the dense spacing of photoreceptors in the human retina
March 16, 2017

nanowire device ft

A team of engineers at the University of California San Diego and La Jolla-based startup Nanovision Biosciences Inc. have developed the first nanoengineered retinal prosthesis — a step closer to restoring the ability of neurons in the retina to respond to light.

The technology could help tens of millions of people worldwide suffering from neurodegenerative diseases that affect eyesight, including macular degeneration, retinitis pigmentosa, and loss of… read more

A biocompatible stretchable material for brain implants and ‘electronic skin’

March 10, 2017

stretchy polymer-ft

Stanford chemical engineers have developed a soft, flexible plastic electrode that stretches like rubber but carries electricity like wires — ideal for brain interfaces and other implantable electronics, they report in an open-access March 10 paper in Science Advances.

Developed by Zhenan Bao, a professor of chemical engineering, and his team, the material is still a laboratory prototype, but the team hopes to develop it… read more

Groundbreaking technology rewarms large-scale animal tissues preserved at low temperatures

A major step toward long-term preservation of organs and tissues for transplantation; could lead to saving millions of human lives
March 2, 2017

Inductive heating of magnetic nanoparticles warms tissue preserved at very low temperatures without damage (credit: Navid Manuchehrabadi et al./Science Translational Medicine)

A research team led by the University of Minnesota has discovered a way to rewarm large-scale animal heart valves and blood vessels preserved at very low (cryogenic) temperatures without damaging the tissue. The discovery could one day lead to saving millions of human lives by creating cryogenic tissue and organ banks of organs and tissues for transplantation.

The research was published March 1… read more

Why you should eat 10 portions of fruit or vegetables a day

February 24, 2017

image credit | iStock

Eating 800 grams a day (about ten portions*) of fruit or vegetables could reduce your chance of heart attack, stroke, cancer, and early death, scientists from Imperial College London conclude from a meta-analysis of 95 studies on fruit and vegetable intake.

The study, published in an open-access paper in the International Journal of Epidemiology, included 2 million people worldwide and assessed up to 43,000 cases… read more

How to build your own bio-bot

Building blocks for the biomachines of the future
February 14, 2017

Bio-bot design inspired by the muscle-tendon-bone complex found in the human body, with 3D-printed flexible skeleton. Optical stimulation of the muscle tissue (orange), which is genetically engineered to contract in response to blue light, makes the bio-bot walk across a surface in the direction of the light. (credit: Ritu Raman et al./Nature Protocols)

For the past several years, researchers at the University of Illinois at Urbana-Champaign have reverse-engineered native biological tissues and organs — creating tiny walking “bio-bots” powered by muscle cells and controlled with electrical and optical pulses.

Now, in an open-access cover paper in Nature Protocols, the researchers are sharing a protocol with engineering details for their current generation of millimeter-scale soft robotic bio-bots*.

Using 3D-printed skeletons, these… read more

Soft robotic sleeve developed to aid failing hearts

Could be implanted to restore blood circulation
January 27, 2017

A soft robotic sleeve placed around the heart in a pig model of acute heart failure. The actuators embedded in the sleeve support heart function by mimicking the outer heart muscles that induce the heart to beat. (credit: Harvard SEAS)

An international team of scientists has developed a soft robotic sleeve that can be implanted on the external surface of the heart to restore blood circulation in pigs (and possibly humans in the future) whose hearts have stopped beating.

The device is a silicone-based system with two layers of actuators: one that squeezes circumferentially and one that squeezes diagonally, both designed to mimic the movement of healthy hearts when… read more

A deep learning algorithm outperforms some board-certified dermatologists in diagnosis of skin cancer

January 25, 2017

A dermatologist uses a dermatoscope, a type of handheld microscope, to look at skin. Computer scientists at Stanford have created an artificially intelligent diagnosis algorithm for skin cancer that matched the performance of board-certified dermatologists. (Image credit: Matt Young)

Deep learning has been touted for its potential to enhance the diagnosis of diseases, and now a team of researchers at Stanford has developed a deep-learning algorithm that may make this vision a reality for skin cancer.*

The researchers, led by Dr. Sebastian Thrun, an adjunct professor at the Stanford Artificial Intelligence Laboratory, reported in the January 25 issue of Nature that their deep convolutional neural network (CNN) algorithm… read more

A 3D bioprinter that prints fully functional human skin

January 24, 2017

3d skin bioprinter ft

A prototype 3D bioprinter that can create totally functional human skin has been developed by scientists from Universidad Carlos III de Madrid (UC3M) and BioDan Group in Spain. The skin has been used to treat burns as well as traumatic and surgical wounds in a large number of patients in Spain, according to the scientists.

The system provides two processes.

Autologous skin (from… read more

A ‘smart’ patch that automatically delivers insulin when needed

Replaces finger-pricking and insulin shots
January 20, 2017

Tiny, painless microneedles on a patch can deliver insulin in response to rising glucose levels. (credit: American Chemical Society)

A team of scientists has invented a replacement for daily glucose-level finger-pricking and insulin shots: a painless “smart” patch that monitors blood glucose and releases insulin when levels climb too high.

The report on the device, which has only been tested on mice so far, appears in the journal ACS Nano.

People with Type 1 diabetes don’t make insulin — a hormone that regulates blood glucose (sugar). Those with… read more

Wearable sensors can alert you when you are getting sick, Stanford study shows

January 18, 2017

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Fitness monitors and other wearable biosensors can tell when your heart rate, activity, skin temperature, and other measures are abnormal, suggesting possible illness, including the onset of infection, inflammation, and even insulin resistance, according to a study by researchers at the Stanford University School of Medicine.

The team collected nearly 2 billion measurements from 60 people, including continuous data from each participant’s wearable biosensor devices* and periodic data… read more

Intricate microdevices that can be safely implanted

Applications include a drug-delivery system to provide tailored drug doses for precision medicine, catheters, stents, cardiac pacemakers, and soft microbotics
January 13, 2017

Implantable microrobots ft

Columbia Engineering researchers have invented a technique for manufacturing complex microdevices with three-dimensional, freely moving parts made from biomaterials that can safely be implanted in the body. Potential applications include a drug-delivery system to provide tailored drug doses for precision medicine, catheters, stents, cardiac pacemakers, and soft microbotics.

Most current implantable microdevices have static components rather than moving parts and, because they require batteries or other toxic… read more

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