<?xml version="1.0" encoding="UTF-8"?><rss version="2.0"
	xmlns:content="http://purl.org/rss/1.0/modules/content/"
	xmlns:dc="http://purl.org/dc/elements/1.1/"
	xmlns:atom="http://www.w3.org/2005/Atom"
	xmlns:sy="http://purl.org/rss/1.0/modules/syndication/"
		>
<channel>
	<title>Comments on: Optogenetics illuminates pathways of motivation and depression through brain</title>
	<atom:link href="http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/feed" rel="self" type="application/rss+xml" />
	<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain</link>
	<description>Accelerating Intelligence</description>
	<lastBuildDate>Wed, 19 Jun 2013 01:53:09 +0000</lastBuildDate>
	<sy:updatePeriod>hourly</sy:updatePeriod>
	<sy:updateFrequency>1</sy:updateFrequency>
	<generator>http://wordpress.org/?v=3.4.1</generator>
	<item>
		<title>By: lizardlabs</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-83193</link>
		<dc:creator>lizardlabs</dc:creator>
		<pubDate>Wed, 02 Jan 2013 11:32:08 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-83193</guid>
		<description>I read some of your post and I learned a lot of knowledge from it. Thanks for posting such interesting articles.</description>
		<content:encoded><![CDATA[<p>I read some of your post and I learned a lot of knowledge from it. Thanks for posting such interesting articles.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55650</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 22:23:40 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55650</guid>
		<description>&quot;Then, illuminating the newly light-sensitive regions of the brain stem thought to control motivational movement, Deisseroth and Warden watched the behavioral effects as a subgroup of neurons in the prefrontal cortex that sent connections to the brain stem were activated. They could see not only which cells are possibly involved in motivation, but the way motivation moves from one brain region to another.&quot;

I doubt that a cell is so simple that turning on some reaction to light is the same as doing something else the cell is capable of.  Cells are complicated, and have many gates and channels, and cell activity is not uniform and designed to do the same things or triggered by all one mechanism...we cannot be so simplistic.  Some are inhibitory and others excitatory, in the same cell.  Some effects occur when a certain proportion of cells fire, or for a certain duration occurs, or cells with the proper interconnections are accumulated by signal, which can also differ by type of signal or mechanism.</description>
		<content:encoded><![CDATA[<p>&#8220;Then, illuminating the newly light-sensitive regions of the brain stem thought to control motivational movement, Deisseroth and Warden watched the behavioral effects as a subgroup of neurons in the prefrontal cortex that sent connections to the brain stem were activated. They could see not only which cells are possibly involved in motivation, but the way motivation moves from one brain region to another.&#8221;</p>
<p>I doubt that a cell is so simple that turning on some reaction to light is the same as doing something else the cell is capable of.  Cells are complicated, and have many gates and channels, and cell activity is not uniform and designed to do the same things or triggered by all one mechanism&#8230;we cannot be so simplistic.  Some are inhibitory and others excitatory, in the same cell.  Some effects occur when a certain proportion of cells fire, or for a certain duration occurs, or cells with the proper interconnections are accumulated by signal, which can also differ by type of signal or mechanism.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55649</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 22:13:03 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55649</guid>
		<description>Repitition over long consistent periods are necessary to migrate or stimulate growth in receptors.</description>
		<content:encoded><![CDATA[<p>Repitition over long consistent periods are necessary to migrate or stimulate growth in receptors.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55648</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 22:11:28 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55648</guid>
		<description>The brain IS one&#039;s environment, successful signalling produces emotion and  motivation.  If the wires are lit properly, then mood and attention are fine...if wires elsewhere are too active someplace else, then they produce anxiety or autism.</description>
		<content:encoded><![CDATA[<p>The brain IS one&#8217;s environment, successful signalling produces emotion and  motivation.  If the wires are lit properly, then mood and attention are fine&#8230;if wires elsewhere are too active someplace else, then they produce anxiety or autism.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55647</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 22:04:57 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55647</guid>
		<description>Why not just use drugs or other forms of &quot;soma&quot; available today?</description>
		<content:encoded><![CDATA[<p>Why not just use drugs or other forms of &#8220;soma&#8221; available today?</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55645</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 22:02:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55645</guid>
		<description>&quot; We need to imposed the UN to exemplify justice, not to cower behind closed doors and promulgate the will of the few.&quot;    

Now THAT&#039;s the purpose and function of democracy: to promulgate the will of the few...it is just an alternative method to other political systems, but it has the exact same large outcome as any other system: an alternative to outright murder and lawlessness, period.  Just a variation of form, not of function, to any other conquest based enterprise, which is: dominance of the many by the few, and in as many ways as possible.   

If by programming we can replace animal instinct (reptile brain) influences that subtly weave us right back into excesses, then THAT&#039;s the reason for advances...and learning the HOW, not the WHY.  Thus we can re-wire ourselves to avoid irrational destructive excesses, by bypassing the reptilian and animal &quot;in-humane&quot; excesses when we don&#039;t need more food or shelter or knowledge or power in our immediate persons.  The UN is just another iteration of the same old power and brutality of our reptilian impulses dominating to excess.</description>
		<content:encoded><![CDATA[<p>&#8221; We need to imposed the UN to exemplify justice, not to cower behind closed doors and promulgate the will of the few.&#8221;    </p>
<p>Now THAT&#8217;s the purpose and function of democracy: to promulgate the will of the few&#8230;it is just an alternative method to other political systems, but it has the exact same large outcome as any other system: an alternative to outright murder and lawlessness, period.  Just a variation of form, not of function, to any other conquest based enterprise, which is: dominance of the many by the few, and in as many ways as possible.   </p>
<p>If by programming we can replace animal instinct (reptile brain) influences that subtly weave us right back into excesses, then THAT&#8217;s the reason for advances&#8230;and learning the HOW, not the WHY.  Thus we can re-wire ourselves to avoid irrational destructive excesses, by bypassing the reptilian and animal &#8220;in-humane&#8221; excesses when we don&#8217;t need more food or shelter or knowledge or power in our immediate persons.  The UN is just another iteration of the same old power and brutality of our reptilian impulses dominating to excess.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: marek pyka</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-55643</link>
		<dc:creator>marek pyka</dc:creator>
		<pubDate>Fri, 23 Nov 2012 21:54:12 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-55643</guid>
		<description>&quot; we will have to understand why we do them in the first place..  

No, just how.  Why is anthropomorphic projection, a source of error.  

&quot;That is the central idea of democracy.&quot;  You&#039;re joking, right?  Or are you projecting again?  That is a very lazy scientist, to bypass the scientific method that actually produces advances.</description>
		<content:encoded><![CDATA[<p>&#8221; we will have to understand why we do them in the first place..  </p>
<p>No, just how.  Why is anthropomorphic projection, a source of error.  </p>
<p>&#8220;That is the central idea of democracy.&#8221;  You&#8217;re joking, right?  Or are you projecting again?  That is a very lazy scientist, to bypass the scientific method that actually produces advances.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Bri</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-54614</link>
		<dc:creator>Bri</dc:creator>
		<pubDate>Tue, 20 Nov 2012 22:31:11 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-54614</guid>
		<description>The implications of this type of research are far ranging. It is essential for an understanding of how human intelligence works. If we are to get robots to do things on their own, we will have to understand why we do them in the first place.. The same old issue of promise and peril looms large. It&#039;s the same issue that is at the heart of UN oversight of the Internet. Once we can control a persons or robots motivation, what do we intend to do with it? Who should make those decisions? Who watches the watchmen? Hopefully it is us. That is the central idea of democracy. That the constituents educate themselves and engage the political system. Once we can control motivation, an individual or our government could send a robotic bee in through your window , and alter who you are. We need to engage in a much more thurough discussion of morals and ethics, and how these relate to everyone. Especially our governments. Honestly I don&#039;t think that discussion will take place. Who watches the watchmen? I&#039;m very Jungian. I believe in the collective unconsciousness. The answer was in Ozzy&#039;&#039;s office. I had one that was very similiar. Mine didn&#039;t have a makeup palette commemorating tha unification of the two lands. He built his Karnak to glorify his conquests, but that&#039;s not what the other symbols mean. Whoever was in charge of props, wasn&#039;t versed in Egyptian mythology, but none the less, they have a meaning that I have seen since I was very small. We need to imposed the UN to exemplify justice, not to cower behind closed doors and promulgate the will of the few. All these ethical issues will keep rearing their ugly heads, and we need to engage in the debate. We need to empower the individual to work for the  good of the whole, not themselves.</description>
		<content:encoded><![CDATA[<p>The implications of this type of research are far ranging. It is essential for an understanding of how human intelligence works. If we are to get robots to do things on their own, we will have to understand why we do them in the first place.. The same old issue of promise and peril looms large. It&#8217;s the same issue that is at the heart of UN oversight of the Internet. Once we can control a persons or robots motivation, what do we intend to do with it? Who should make those decisions? Who watches the watchmen? Hopefully it is us. That is the central idea of democracy. That the constituents educate themselves and engage the political system. Once we can control motivation, an individual or our government could send a robotic bee in through your window , and alter who you are. We need to engage in a much more thurough discussion of morals and ethics, and how these relate to everyone. Especially our governments. Honestly I don&#8217;t think that discussion will take place. Who watches the watchmen? I&#8217;m very Jungian. I believe in the collective unconsciousness. The answer was in Ozzy&#8221;s office. I had one that was very similiar. Mine didn&#8217;t have a makeup palette commemorating tha unification of the two lands. He built his Karnak to glorify his conquests, but that&#8217;s not what the other symbols mean. Whoever was in charge of props, wasn&#8217;t versed in Egyptian mythology, but none the less, they have a meaning that I have seen since I was very small. We need to imposed the UN to exemplify justice, not to cower behind closed doors and promulgate the will of the few. All these ethical issues will keep rearing their ugly heads, and we need to engage in the debate. We need to empower the individual to work for the  good of the whole, not themselves.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Jerry</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-54605</link>
		<dc:creator>Jerry</dc:creator>
		<pubDate>Tue, 20 Nov 2012 21:28:19 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-54605</guid>
		<description>rTMS and tDCS seems to show some benefits, a quick google showed http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022812 which concluded there was some reduction in negative stimuli during tDCS.

Having clinical depression since early teens I&#039;ve been keeping an eye on the study of tDCS, rTMS and neurofeedback and all three are really showing promise with lasting effects / neuroplasticity. Not sure on addictions though.</description>
		<content:encoded><![CDATA[<p>rTMS and tDCS seems to show some benefits, a quick google showed <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022812" rel="nofollow">http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022812</a> which concluded there was some reduction in negative stimuli during tDCS.</p>
<p>Having clinical depression since early teens I&#8217;ve been keeping an eye on the study of tDCS, rTMS and neurofeedback and all three are really showing promise with lasting effects / neuroplasticity. Not sure on addictions though.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: JC</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-54597</link>
		<dc:creator>JC</dc:creator>
		<pubDate>Tue, 20 Nov 2012 20:36:32 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-54597</guid>
		<description>One implication of the work is that it may be useless to give therapy or drugs to help with motivation in a &#039;relaxing home environment&#039;.  Perhaps we should only bother applying therapy when an engaging challenge is directly in front of the person.</description>
		<content:encoded><![CDATA[<p>One implication of the work is that it may be useless to give therapy or drugs to help with motivation in a &#8216;relaxing home environment&#8217;.  Perhaps we should only bother applying therapy when an engaging challenge is directly in front of the person.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: A4i</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-54596</link>
		<dc:creator>A4i</dc:creator>
		<pubDate>Tue, 20 Nov 2012 20:32:51 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-54596</guid>
		<description>Healthy people may feel themselves depressed, so that condition is not irreversible. Sometimes even the best effort is meaningless. It all depends on how depressant or stimulating is the  environment. The appetite comes in eating. Nothing to eat  - no appetite.</description>
		<content:encoded><![CDATA[<p>Healthy people may feel themselves depressed, so that condition is not irreversible. Sometimes even the best effort is meaningless. It all depends on how depressant or stimulating is the  environment. The appetite comes in eating. Nothing to eat  &#8211; no appetite.</p>
]]></content:encoded>
	</item>
	<item>
		<title>By: Sherrie</title>
		<link>http://www.kurzweilai.net/optogenetics-illuminates-pathways-of-motivation-and-depression-through-brain/comment-page-1#comment-54564</link>
		<dc:creator>Sherrie</dc:creator>
		<pubDate>Tue, 20 Nov 2012 17:12:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.kurzweilai.net/?p=171544#comment-54564</guid>
		<description>Great work. Can the pathways be stimulated by other means, non0nvasive and external to reduce suffering in humans, if not now, eventually?  Could this type of approach be used with addictions?</description>
		<content:encoded><![CDATA[<p>Great work. Can the pathways be stimulated by other means, non0nvasive and external to reduce suffering in humans, if not now, eventually?  Could this type of approach be used with addictions?</p>
]]></content:encoded>
	</item>
</channel>
</rss>
