A special, free news feature in Science magazine explores 125 big questions that face scientific inquiry over the next quarter-century.

The questions include:

What Is the Universe Made Of?

What is the Biological Basis of Consciousness?

Why Do Humans Have So Few Genes?

To What Extent Are Genetic Variation and Personal Health Linked?

How Far Can We Push Chemical Self-Assembly?

What Are the Limits of Conventional Computing?