Therapies using induced pluripotent stem cells could encounter immune rejection problems
May 16, 2011
The researchers tested the immune response of an inbred strain of mice to embryonic stem cells and several types of iPSCs derived from the same strain of inbred mice.
They found that the immune system of one mouse could not recognize the cells derived from embryonic stem cells of the same strain of mice.
Their experiments also showed that the immune system rejected cells derived from iPSCs reprogrammed from fibroblasts of the same strain of mice, mimicking what happens when a patient would be treated with cells derived from iPSCs reprogrammed from the patient’s own cells. They showed that abnormal gene expression during the differentiation of iPSCs causes the immune responses.
Ref: Tongbiao Zhao, Zhen-Ning Zhang, Zhili Rong, Yang Xu, Immunogenicity of induced pluripotent stem cells, Nature, 2011; DOI: 10.1038/nature10135