‘Virus-like’ nanoparticle built to target tumors
August 20, 2012
National Cancer Institute scientists have built fully synthetic self-assembling virus-like nanoparticles that fuse with cells like real viruses, Nature News Blog reports.
Viruses are extremely effective at targeting cells and delivering proteins into them. To mimic a virus, the team used amino acids to build a molecule that resembles a known protein that spans cell membranes.
The team previously described how these proteins self-assemble into spherical nanoparticles in solution. Now the team has gone further, showing that these nanoparticles can fuse with cells via receptors.
By incorporating compounds into their nanoparticles that normally bind prostate tumor cells, their virus-mimic selectively targets these cells. They can be used to encapsulate drugs, meaning that a synthetic virus-like particle could be created to target cancer cells and then deliver a chemotherapy payload precisely to the tumor.
- Sergey G. Tarasov, Vadim Gaponenkob, O. M. Zack Howard, Yuhong Chen, Joost J. Oppenheim, Marzena A. Dyba, Sriram Subramaniam, Youngshim Lee, Christopher Michejda, Nadya I. Tarasova, Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles, Proceedings of the National Academy of Sciences, 2011, DOI: 10.1073/pnas.1014598108 (open access)