25 results

[ News ] Deep-brain imaging using minimally invasive surgical needle and laser light

March 20, 2017

This is an image of cells taken inside the mouse brain using a new method developed by University of Utah electrical and computer engineering associate professor Rajesh Menon and his team. (credit: Rajesh Menon)

Using just a simple inexpensive micro-thin glass surgical needle and laser light, University of Utah engineers have developed an inexpensive way to take high-resolution pictures of a mouse brain, minimizing tissue damage — a process they believe could lead to a much less invasive method for humans.

Typically, researchers must either surgically take a sample of the animal’s brain to examine the cells under a microscope or use… read more

[ News ] How to detect early signs of Alzheimer’s with a simple eye exam before symptoms appear

July 12, 2016

retina - red wavelength ft

University of Minnesota (UMN) scientists and associates have developed new technology that can detect signs of Alzheimer’s before the onset of symptoms — early enough to give drugs a chance to work — in mice and humans by simply examining the back of their eyes.

Looking at Alzheimer’s effects through the eye is a key advantage of the new technology. “The retina of the eye is not just ‘connected’… read more

[ News ] Deep-brain imaging reveals which nearly identical neurons are associated with specific behaviors

January 30, 2015

Integration of the miniepifluorescence microscope with the microendoscope for deep-brain imaging of LH GABAergic neurons expressing GCaMP6m (credit: Joshua H. Jennings et al./Cell)

Researchers at the UNC School of Medicine have used new deep-brain imaging techniques to link the activity of individual, genetically similar neurons to particular behaviors of freely moving mice.

For the first time ever, scientists watched as one neuron was activated when a mouse searched for food while a nearly identical neuron next to it remained inactive; instead, the second neuron only became activated when the mouse began… read more

[ News ] Robot uses steerable needles to treat brain clots

August 9, 2013

steerable_needle_robot

Vanderbilt University researchers are developing an image-guided robotic surgical system to remove blood clots in the brain.

It uses steerable needles about the size of those used for biopsies to penetrate the brain with minimal damage and suction away the blood clot that has formed.

The odds of a person getting an intracerebral hemorrhage are one in 50 over his or her lifetime. When… read more

[ News ] Nanotools for neuroscience and brain activity mapping

March 25, 2013

SEM_of_rat_cortical_cell

“Neuroscience — one of the greatest challenges facing science and engineering — is at a crossroads. …There exist few general theories or principles that explain brain function [due partly to] limitations in current methodologies,” say neuroscientists in a new ACS Nano open-access paper, “Nanotools for Neuroscience and Brain Activity Mapping.”

Traditional neurophysiological approaches record the activities of one neuron or a few neurons at a time. Neurochemical… read more

[ News ] A high-resolution endoscope as thin as a human hair

March 13, 2013

Kahn_spot_endoscope_stanford

Engineers at Stanford University have developed a prototype single-fiber endoscope that is as thin as a human hair, with a resolution four times better than previous devices of similar design.

The “micro-endoscope” is a significant step forward in high-resolution, minimally invasive bioimaging, with potential applications in research and clinical practice. Micro-endoscopy could enable new methods in diverse fields ranging from study of the brain to early cancer… read more

[ News ] New imaging technologies transforming medicine

October 9, 2012

fantastic-voyage

A new wave of imaging technologies is transforming the practice of medicine, The New York Times reports, to give doctors an instantaneous diagnosis, as well as inexpensive systems, often based on smartphones, that can extend advanced imaging technologies to the entire world.

Driven largely by the falling cost of computing and the increasing availability of other miniaturization technologies, including nanotechnology, they include:

  • Endoscopes that use

read more

[ News ] Wireless power system replaces batteries in implants

September 5, 2012

High-frequency wireless power transmission to a device in the human heart. Red indicates greatest power; blue is least. (Credit: John Ho, Stanford Engineering)

Stanford University engineers have demonstrated the feasibility of a super-small, implantable cardiac device that gets its power from radio waves transmitted from a small transmitter on the surface of the body.

This is an impressive achievement that may lead to replacing bulky batteries in implants. That means the implants can be further miniaturized, while eliminating surgery to replace or charge batteries (or require a wired connection outside the body).… read more

[ News ] A nanowire endoscope for imaging inside a single cell

December 22, 2011

Endoscope Sensing

An endoscope that can provide high-resolution optical images of the interior of a single living cell, or precisely deliver genes, proteins, therapeutic drugs or other cargo without injuring or damaging the cell, has been developed by researchers from Berkeley Lab and the University of California (UC) Berkeley.

The researchers  attached a tin-oxide nanowire waveguide to the tapered end of an optical fiber to create a novel endoscope system. Light… read more

[ News ] ‘Fantastic Voyage’ through the digestive track

December 19, 2011

Illustration of an endoscopic capsule, propelled by magnetic swimming tails (1). The capsule payload is a micro-camera (5) and tool for biopsy (4). The power source is non-magnetic batteries (2). There is also electronics for command and control and communication (7), housing (8), and an antenna (3) for the RF transceiver. (Credit: Gábor Kósa et al.)

In a scene out of the movie Fantastic Voyage, Dr. Gabor Kosa of Tel Aviv University has developed a wireless “capsule endoscope” that can be remotely steered through the digestive tract to detect problem like hidden tumors or wounds, or allow for treatments such as biopsies or local drug delivery.

However, rather than miniaturized people (the technology is not quite there yet), the device is remotely… read more

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