University of Toyama researchers have built the first DNA molecule made almost entirely of artificial parts.

The researchers used DNA synthesis equipment to assemble four artificial bases (basic building blocks of DNA) inside the framework of a DNA molecule. The unusually stable, double-stranded structures resemble natural DNA, which also has four bases.

Until now, scientists have only been able to craft DNA molecules with one or a few artificial parts, including certain bases.

The finding could lead to nanocomputers, improvements in gene therapy, and other high-tech advances.

Artificial DNA Made Exclusively of Nonnatural C-Nucleosides with Four Types of Nonnatural Bases