An experimental and potentially powerful way to fight disease, called RNA interference (RNAi), could now be closer to reality, as researchers at MIT and Alnylam, a biotech company based in Cambridge, MA, have addressed a key obstacle to effectively delivering the treatment to targeted cells.

The researchers report a method for quickly synthesizing more than a thousand different lipid-like molecules and screening them for their ability to deliver short RNA molecules to cells. They’ve shown that some of these delivery agents are 10 times as effective at delivering RNA than previous methods were.