The Enthusiast

August 17, 2007 | Source: Technology Review

David Sinclair, a controversial Harvard biologist, claims he can extend life span and treat diseases of aging.

He discovered that resveratrol, a chemical found in red wine, extends life span in mice by up to 24 percent and in other animals, including flies and worms, by as much as 59 percent. Sinclair hopes that resveratrol will bump up the life span of people, too.

Sinclair thinks resveratrol works by activating SIRT1, a gene that many scientists believe plays a fundamental role in regulating life span in animals. Biologists have found that increasing the expression of SIRT1 slows aging and fends off maladies associated with growing old, including cancer and heart disease. If Sinclair is right, and resveratrol can activate SIRT1–and if the gene does in fact help control aging–he has found something truly remarkable.