Turning Back the Bio Clock

March 15, 2004 | Source: Wired News

Researchers are hard at work building biological time machines that reverse aging in some cells.

Some are trying to reset biological clocks by mimicking “magic factors” in human eggs — the only cells in a woman’s body not programmed to die. Others are identifying molecules that enable salamanders to re-grow limbs. Chemists in San Diego have created a chemical compound they call “reversine,” which resets muscle cells in mice much the same way newts restart limb cell growth after injury. A Scripps Research Institute team has created a small molecule that reverses the aging process of mouse muscle cells, turning them into “stem-like cells” and then re-growing them into different cells. And a University College London researcher has isolated an enzyme implicated in the salamander’s ability to re-grow an eye lens after it has been surgically removed.